TMT™ (Tandem Mass Tag™) Technology

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TMT™ (Tandem Mass Tag™) technology is a peptide labeling technique developed by Thermo Scientific, Inc. Westlake Omics uses the latest TMTpro™ 16plex isotope labeling reagent set to perform tandem mass spectrometry analysis by specifically labeling specific amino groups of peptides, allowing the simultaneous relative quantification of proteins of up to 16 different samples. TMT labeled peptides are typically acquired in DDA (Data-Dependent Acquisition) mode (labeled DDA).

Application Scenarios: A TMT labeling strategy is preferred for in-depth proteomic identification.

 

Mass Spectrometer: Orbitrap Exploris™ 480

 

References:

1.Li, et al, TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples. Nature Methods. 2020. (17): 399-404.

https://www.nature.com/articles/s41592-020-0781-4

2.Shen, et al. Proteomic and Metabolomic Characterization of COVID-19 Patient Sera. Cell. 2020. 182(1): 59-72.

https://www.cell.com/cell/fulltext/S0092-8674(20)30627-9

3.Nie, et al. Multi-organ Proteomic Landscape of COVID-19 Autopsies. Cell. 2021 Feb.184(3): 775-791.

https://www.sciencedirect.com/science/article/pii/S0092867421000040

4.Zhu, et al. Snapshot: Clinical proteomics. Cell. 2021.184(18): 4840-4840.

https://www.sciencedirect.com/science/article/abs/pii/S0092867421009855

5.Bi, et al. Proteomic and metabolomic profiling of urine uncovers immune responses in COVID-19. Cell Reports. 2021. 38(3)

https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01783-6#

TMT™ (Tandem Mass Tag™) technology is a peptide labeling technique developed by Thermo Scientific, Inc. Westlake Omics uses the latest TMTpro™ 16plex isotope labeling reagent set to perform tandem mass spectrometry analysis by specifically labeling specific amino groups of peptides, allowing the simultaneous relative quantification of proteins of up to 16 different samples. TMT labeled peptides are typically acquired in DDA (Data-Dependent Acquisition) mode (labeled DDA).

Application Scenarios: A TMT labeling strategy is preferred for in-depth proteomic identification.

 

Mass Spectrometer: Orbitrap Exploris™ 480

 

References:

1.Li, et al, TMTpro reagents: a set of isobaric labeling mass tags enables simultaneous proteome-wide measurements across 16 samples. Nature Methods. 2020. (17): 399-404.

https://www.nature.com/articles/s41592-020-0781-4

2.Shen, et al. Proteomic and Metabolomic Characterization of COVID-19 Patient Sera. Cell. 2020. 182(1): 59-72.

https://www.cell.com/cell/fulltext/S0092-8674(20)30627-9

3.Nie, et al. Multi-organ Proteomic Landscape of COVID-19 Autopsies. Cell. 2021 Feb.184(3): 775-791.

https://www.sciencedirect.com/science/article/pii/S0092867421000040

4.Zhu, et al. Snapshot: Clinical proteomics. Cell. 2021.184(18): 4840-4840.

https://www.sciencedirect.com/science/article/abs/pii/S0092867421009855

5.Bi, et al. Proteomic and metabolomic profiling of urine uncovers immune responses in COVID-19. Cell Reports. 2021. 38(3)

https://www.cell.com/cell-reports/fulltext/S2211-1247(21)01783-6#

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